Cassiopeia vs Zoe in Mid lane is a skill matchup on patch 26.16. The one thing to respect: her E, Sleepy Bubble — it's her biggest threat and sets up her whole combo. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDZOEthe Aspect of Twilight

VS

Skill matchupPre-6 MediumPost-6 MediumTake Teleport

How to play it

✓ DO

Cleanse her E

Her E is her biggest threat — it's worth Cleansing unless she can't follow up with a long-range Q.

Fight on her CDs

All-in when her abilities are down — with no stolen W spell and E on CD she has no burst or escape.

Don't hug minions

Her Q hits an area around minions and does more damage the further it travels — walk off the wave when she Qs.

✕ DON'T

⛔

Never fight her while she has a stolen spell from W — it gives her extra move speed and damage.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

Last 30 days Emerald+ - 50% WR - 768 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →