Cassiopeia vs Katarina in Mid lane is a favourable lane on patch 26.16. The one thing to respect: her R is the only real threat — it faces where she aimed before the cast, so kite out of it. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDKATARINAthe Sinister Blade

VS

Favors youPre-6 EasyPost-6 EasyTake Teleport

How to play it

✓ DO

Kite her R

Death Lotus faces the direction she was turned before casting, so kite out sideways; it also applies grievous wounds.

Zone off her Q

Her only ranged waveclear is her Q, so zone her off CS while it's on cooldown.

Poison her dagger jumps

Stand away from her daggers unless you'll win, and poison her the moment she E's onto one.

✕ DON'T

⛔

Never sit in her daggers when you can't win the trade — each one she collects refunds her E.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 52% WR - 435 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →