Cassiopeia vs Annie in Mid lane is a lane that swings with levels on patch 26.16. The one thing to respect: her ult (Tibbers) is the whole matchup — it bursts you and keeps attacking, so only fight when it's down. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDANNIEthe Dark Child

VS

Swings with levelsPre-6 MediumPost-6 HardTake Teleport

How to play it

✓ DO

Only fight ult-down

Her ult is her main threat — it does burst damage and keeps attacking, so until you're tanky only fight when it's on cooldown.

Poke from range

Q her from outside her range — her Q and W are outranged by all your abilities, so chip her and bait her spells safely.

Count her stun

After she casts four spells a white swirl appears and her next ability stuns — her targeted Q makes it very reliable, so back off when she's charged.

✕ DON'T

⛔

Never all-in while her ult is up — until you're tanky enough her burst kills you, and Tibbers only gets stronger if she dies.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

Last 30 days Emerald+ - 43% WR - 511 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

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