Cassiopeia vs Orianna in Mid lane is a hard lane on patch 26.16. The one thing to respect: her ult fires from her ball and cuts off your escape — stay clear of the ball. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDORIANNAthe Lady of Clockwork

VS

Heavily unfavoredPre-6 HardPost-6 HardTake Teleport

How to play it

✓ DO

Respect her ult

Her R fires from where her ball is, so keep distance from the ball; Flash out if it catches you.

Punish her E cooldown

While her E shield is down she has no resistances — trade then, especially if her Q is also on CD.

Block her Q

Her Q deals less the more minions it passes through, so keep a minion between you and her ball.

✕ DON'T

⛔

Never linger near her ball while her ult is up — it fires from the ball and cuts off your escape.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 55% WR - 282 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →