Cassiopeia vs Ryze in Mid lane is a favourable lane on patch 26.16. The one thing to respect: his Q Overload is his main damage — only trade when you can dodge it. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDRYZEthe Rune Mage

VS

Favors youPre-6 EasyPost-6 EasyTake Teleport

How to play it

✓ DO

Dodge his Q

Overload is his main damage and resets off his W and E — only take trades where you can sidestep it or land a free auto.

Punish his E cooldown

His E is his combo amp; the brief moment it's on its short cooldown he's at his weakest — go in then.

Poison wins fights

You win every extended fight if you land poison — later, abuse him whenever his spells are down or out of range.

✕ DON'T

⛔

Never bunch up on the minion wave — his E spreads onto you from nearby minions.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 51% WR - 374 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →