Cassiopeia vs Zed in Mid lane is a skill matchup on patch 26.16. The one thing to respect: his R (Death Mark) is the kill — pop Stopwatch/Zhonya's the instant he ults. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDZEDthe Master of Shadows

VS

Skill matchupPre-6 MediumPost-6 MediumTake Teleport

How to play it

✓ DO

Zhonya's his R

When he Death Marks you, use Stopwatch/Zhonya's immediately (or within 3 secs after) so you take zero ult damage; with Exhaust, hit him the moment he lands.

Punish his W down

His W is a 20s CD lasting only 5s — when it's on cooldown he loses most of his all-in, so pressure him then.

Poke through minions

His Q does less damage the more minions it passes through, so poke and farm from behind your wave; rush armor since he's an AD assassin.

✕ DON'T

⛔

Never hold your Stopwatch/Zhonya's too long — pop it the moment Zed ults, or within 3 seconds, so you take no ult damage.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 53% WR - 400 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →