Cassiopeia vs Vladimir in Mid lane is a favourable lane on patch 26.16. The one thing to respect: his empowered Q's — stay outside 600 range of them; they hit and heal for far more than his basic Transfusion. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDVLADIMIRthe Crimson Reaper

VS

Favors youPre-6 EasyPost-6 EasyTake Teleport

How to play it

✓ DO

Dodge empowered Q

Stay outside 600 range of his empowered Q's — they deal far more damage and healing, so only eat one if you're committing to an extended fight.

Space with your range

His E is only 600 range and blocked by minions — poke him with your full kit from outside it and he can't answer.

Bait his pool

His W pool is a 28s cooldown and he has far less outplay while it's down — W him first and he stays grounded and slowed inside it.

✕ DON'T

⛔

Never sit inside 600 range of his empowered Q — that's the one thing that lets him out-trade you.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 50% WR - 354 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →