Cassiopeia vs Twisted Fate in Mid lane is a favourable lane on patch 26.16. The one thing to respect: his W (Pick a Card) — his one real threat, but it's only auto-range. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDTWISTED FATEthe Card Master

VS

Favors youPre-6 EasyPost-6 EasyTake Teleport

How to play it

✓ DO

Respect his W

His W is his main threat, but it only reaches auto range (525) — every ability of yours outranges it.

Poison wins trades

You win extended trades once your poison is on him — space outside his autos or wait out his W.

Cancel his ult

His R channels ~1.5s — if you're nearby, cancel it with your W or R stun.

✕ DON'T

⛔

Never fight inside his auto range with your poison expired — that's the only way he out-trades you.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 48% WR - 326 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →