Cassiopeia vs Syndra in Mid lane is a hard lane on patch 26.16. The one thing to respect: respect her E — she chunks you with it and can stun off the Dark Spheres around you. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDSYNDRAthe Dark Sovereign

VS

Heavily unfavoredPre-6 HardPost-6 HardTake Teleport

How to play it

✓ DO

Don't line up with spheres

Avoid lining up with her Dark Spheres — her low-cooldown E chunks you and stuns, often set up by her hard-to-dodge W slow.

Don't trade Q's late

Post level 8, don't trade Q for Q — hers costs less mana and does more damage, unless you can dodge hers or need the CS.

Punish her E on cooldown

When her E is down (or you'll burn summoners to dodge it), you have a window to play aggressive.

✕ DON'T

⛔

Never step into her 675-range ult unless you're tanky enough to survive the burst.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 46% WR - 706 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →