Cassiopeia vs Lissandra in Mid lane is a favourable lane on patch 26.16. The one thing to respect: her Q is her only real damage — don't line up with your minions, and your Q outranges it anyway. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDCASSIOPEIAthe Serpent's Embrace

⇄ ChangeENEMY · MIDLISSANDRAthe Ice Witch

VS

Favors youPre-6 EasyPost-6 EasyTake Teleport

How to play it

✓ DO

Dodge her Q line

Her Q is her main damage and still hits soft — don't stand in line between her and your minions (it gains range), and your Q outranges it at 825.

Punish her E on CD

While her E is down she can only escape or reach you by Flashing — that's the window to commit and all-in.

Don't overcommit on R

Her point-and-click R stuns for 1.5s, but she can instead self-cast it for a 2.5s Zhonya's-style stasis — don't dive in for a kill she can just deny.

✕ DON'T

⛔

Never overcommit into her ult range — she can self-cast R for a 2.5s stasis to survive and reset, so a greedy dive just gets punished.

Runes

SORCERY

PRECISIONuniversal page

SHARDS

No rune change for this matchup — run the universal page, our every-game default.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 47% WR - 278 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
		Q							Q	Q		Q	Q
			W											W	W		W	W
	E			E	E		E	E
						R					R					R

MAXE→Q→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →