Ryze vs Vladimir in Mid lane is a skill matchup on patch 26.16. The one thing to respect: his Q (Transfusion) sustain — don't let Vladimir regen health for free between trades. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDRYZEthe Rune Mage

⇄ ChangeENEMY · MIDVLADIMIRthe Crimson Reaper

VS

Skill matchupPre-6 MediumPost-6 MediumTake Teleport

How to play it

✓ DO

Deny his Q heal

Don't let him regen for free — keep constant pressure so his Transfusion Q never heals him back to full.

Extend your trades

Extend every trade — Vladimir has long cooldowns early and you have more sustained DPS, so drag the fight out.

Hit your spells

Land all your spells — hit your combo cleanly and you win this lane outright.

✕ DON'T

⛔

Never let Vladimir sit back and heal to full for free — keep the pressure on him.

Runes

SORCERYmatchup page

RESOLVEoverride for this matchup

SHARDS

Matchup-specific rune page — override from the OTP sheet for this lane.

Spells

FLASH

TELEPORT

Items

Start

Core

→

→

16.14 Emerald+ - 48% WR - 511 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
	Q			Q	Q		Q	Q
			W											W	W		W	W
		E							E	E		E	E
						R					R					R

MAXQ→E→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →