Ryze vs Cassiopeia in Mid lane is a lane to avoid on patch 26.16. The one thing to respect: She outranges and outdamages you — only trade when she whiffs her Q. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

⇄ ChangeYOU · MIDRYZEthe Rune Mage

⇄ ChangeENEMY · MIDCASSIOPEIAthe Serpent's Embrace

VS

Avoid — ban or dodgePre-6 UnplayablePost-6 UnplayableTake Ghost

How to play it

✓ DO

Trade on a missed Q

Only trade when she misses her Q (Noxious Blast) — otherwise she outranges, outdamages and out-sustains your mana.

Set up your jungler

She's easy to gank — bring your jungler and it's a clean, easy kill.

Kite with Stormraider's Surge

Dump as many spells as you can, then kite out with Stormraider's Surge.

✕ DON'T

⛔

Never trade into her while her Q is up — she has more range, more damage and cheaper spells.

Runes

SORCERYmatchup page

RESOLVEoverride for this matchup

SHARDS

Matchup-specific rune page — override from the OTP sheet for this lane.

Spells

FLASH

GHOST

Items

Start

Core

→

→

16.14 Emerald+ - 53% WR - 361 games

Skill order

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
	Q			Q	Q		Q	Q
			W											W	W		W	W
		E							E	E		E	E
						R					R					R

MAXQ→E→W

IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.

IMPROVE YOUR MACRO →