Matchups › Qiyana › vs Karthus

Qiyana vs Karthus

QiyanaYOU · MID
KarthusENEMY · MID
VS
Skill matchupPre-6 MediumPost-6 MediumTake Ignite

How to play it

Dodge his Q
his abilities are easy to sidestep, and dodging Lay Waste is the whole matchup.
Bait his Exhaust
He usually takes Exhaust into you: bait it with E-Q (grass) and W-Q (rock) before you commit the kill.
Don't trade kills
Never trade kills: he uses the gold better since he only has to press R to matter even while dead.
Never trade kills with him: even dead he presses R to stay useful and turns the gold into more value than you.
Runes
DOMINATIONDOMINATION
Electrocute
Dark Harvest
Hail of Blades
Cheap Shot
Taste of Blood
Sudden Impact
Sixth Sense
Grisly Mementos
Deep Ward
Treasure Hunter
Relentless Hunter
Ultimate Hunter
PRECISIONPRECISION
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
IgniteIGNITE
Items
Start
Core
Last 30 days Emerald+ - 49% WR - 693 games
Skill order
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QQQQQ
WWWWW
EEEEE
RRR
MAXQQWWEE
Qiyana · Mid · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Qiyana vs Karthus in Mid lane is a skill matchup on patch 26.17. The one thing to respect: Dodge his Q, Lay Waste is his damage; sidestep it and the rest of his kit is easy to dodge.

Qiyana matchup data made by the group contribution of Qiyana OTP mainsLeague of Legends assets © Riot Games (Data Dragon).